tag:blogger.com,1999:blog-232366517985764330.post6004874001864742481..comments2023-09-12T02:41:53.313-07:00Comments on Happily Ever After: Sperm DNA FragmentationAmyhttp://www.blogger.com/profile/05141404945991036043noreply@blogger.comBlogger26125tag:blogger.com,1999:blog-232366517985764330.post-71935802169970116852012-10-29T07:35:09.159-07:002012-10-29T07:35:09.159-07:00We have been trying for 5 years. The final diagnos...We have been trying for 5 years. The final diagnosis after IVF failure was "unexplained infertility." We then went to an endocrinologist who specializes in infertility. He discovered that my husband has very high fregmantation. He prescribed gonadotropins to him for 3 months. (I am sorry I don't have the brand-name of the drug). The MD told us that after treatment he will be fertile for 2-4 months. He expects us to conceive naturally. However, IVF might be needed again. <br />This is all very promising! I still don't know if it will actually work, but I wanted to share it with you because I know that for those who try knowledge is treasure! <br />Good luck!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-24424209798153795162012-06-05T11:13:42.765-07:002012-06-05T11:13:42.765-07:00Gooogle diclofenac (its an nsaid for arthritis)and...Gooogle diclofenac (its an nsaid for arthritis)and sperm fragmentation there is an artical that says the drug helps with the fragmentation. We have been on this journey a long time. We have no problem getting pregnant it just dissolves right around week 3-4from lmpAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-72665800657423576162012-05-05T10:44:40.895-07:002012-05-05T10:44:40.895-07:00Hi,
My husband has a high DNA fragmentation > ...Hi, <br />My husband has a high DNA fragmentation > 50% and also low sperm morphology 2% normal. <br /><br />We are so confused and scared to try any of the invasive treatment and very disappointed with no proper guidance. I have also suffered 2 miscarriages in the last one year.<br /><br />WE are on antioxidant supplements , but only time will tell us if its effective.<br /><br />Does anyone know of alternate treatment like Homeopathy?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-57645326162079781212012-04-16T14:11:03.239-07:002012-04-16T14:11:03.239-07:00@Mohammed Iraqi: Hi - I just wanted to point out ...@Mohammed Iraqi: Hi - I just wanted to point out to most posters here (and Mohammed) that many languages only have the word "abortion" (which is usually preceded by "involuntary" or "voluntary.") In English the loss of an embryo is called "miscarriage."Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-48834586557344707622012-03-16T15:16:38.840-07:002012-03-16T15:16:38.840-07:00Dear Sir
I have SD level of 22% my wife had 12 ab...Dear Sir <br />I have SD level of 22% my wife had 12 abortions with any successful pregnancy we did a lot of investigations and all normal <br />is the defragmentation levl is the cause <br />please answer me <br />m12md@yahoo.comMohammed iraqihttps://www.blogger.com/profile/01841931090664353620noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-71287354435148767252012-01-22T06:13:52.987-08:002012-01-22T06:13:52.987-08:00I stumbled upon this blog while trying to read mor...I stumbled upon this blog while trying to read more about DNI & its significance in IVF/ICSI. We have been married close to 6 years now and decided to undergo ICSI 2 years ago as we found it most suitable for us after extensive investigation for our infertility issue. Ours is a case of male factor infertility;my husband is oligoasthenospermic.<br /><br />I was able to produce 24 oocytes right in the first attempt and we got 19 well fertilized embryos of that. But the celebration did not last long when one fresh cycle & one frozen cycle failed in quick succession. I did not go back to my clinic for the next 2 years! Last month I decided to give one last shot at the remaining embryos and now that cycle has failed too. We are not left with any more embryos now (we lost many embryos in the thawing process too) & my doctor suggested a fresh cycle when I am ready for it...although I am not sure how many more years I am going to take to gear up to it again now!<br /><br />Meanwhile my doctor also suggested a sperm DNA fragmentation index for my husband along with a SLE & APLA screening for me and that is how I landed upon this website today. Your blog has been a little encouraging at a time when I am almost ready to give up! Thank you for the useful information that you decided to share in your blog. I am already feeling a little positive about going back to my doctor in a few months maybe.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-60795404140777329052011-04-16T18:22:39.072-07:002011-04-16T18:22:39.072-07:00Question for the person who had a DFI of 50% and g...Question for the person who had a DFI of 50% and got pregnant naturally? Do you mind me asking what your sperm motility, count were like? MY hubby has high DFI as well, we failed our first IVF/ICSI, and now his DFI went from 68% (without vitamins) to 37% after a few months of Fertil Pro, and then it started going back up to 50% and the latest result is 87%. He's stopped all alchol and red wine, and it seems the DFI is going up!!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-13290720967649591452011-03-26T13:31:13.543-07:002011-03-26T13:31:13.543-07:00Hi,
I had a DNA fragmentation of 50%,
along wit...Hi, <br /><br />I had a DNA fragmentation of 50%, <br />along with asthenozoospermia. (I'm<br />not sure if they are correlated). <br />On diagnosis, my Doctor put me on Zinc and vitamin suppliments. We were able to conceive naturally within 2 months of start of medicatins, and my wife is into her fourth month now.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-75861845476496815342011-02-05T06:10:48.027-08:002011-02-05T06:10:48.027-08:00Have you looked into embryo adoption? It's rea...Have you looked into embryo adoption? It's really inexpensive. Just a thought. This is the only way my husband and I will ever be able to get pregnant so we have move onto embryo adoption.Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-60372723413455722842011-02-04T19:32:40.143-08:002011-02-04T19:32:40.143-08:00Thank you for your very informative website. Inter...Thank you for your very informative website. Interesting facts on DNA fragmentation. My husband has over 40% DNA frag, I've done 8 IVFs and lost count how many IUIs over the past 4.5 years. Good luck to you trying to get pregnant. I'm going to give up now as I've been thru the wringer while I find the Doctors always check out the female & only once 2 months ago, after 5 years does someone look @ my husband for possible issues! Good luck, I hope you get there!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-36675679141656997432011-01-14T04:42:45.074-08:002011-01-14T04:42:45.074-08:00Hi, we have been through 6 cycles of IVF, mostly I...Hi, we have been through 6 cycles of IVF, mostly ICSI and usually got about 2 thirds fertilize but then not make it to transfer. Out of all those cycles we only had 2 transfers, none frozen and 2 cycles where none fertilized at all which was heartbreaking.<br /><br />Before the last cycle my husband discovered he has about 25% fragmentation. The last cycle they used a high resolution microscope because of this but struggled to find enough good sperm to inject. We had none fertilize again.<br />What I'm wondering is does that mean it was 100% fragmented? Surely if it was 25%, some would have fertilized? Even the doctor said that he doesn't know what else to do except keep trying...<br /><br />Any ideas or has anyone even seen this before? ThanksAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-29621569511944786372010-06-26T08:57:59.238-07:002010-06-26T08:57:59.238-07:00Here is an interesting study. Although the study ...Here is an interesting study. Although the study size was small it shows definite improvement in DNA fragmentation rates by using antioxidants (500 mg Vitamin C twice a day and 500 mg Vitamin E twice a day). <br /><br />http://www.andrologyjournal.org/cgi/reprint/26/3/349.pdf<br /><br />To summarize the study (I am a pharmacist, so I have some experience reviewing drug studies) in the group that was given the antioxidant therapy for 2 months, all 32 patients saw improvement in their DNA fragmentation rates. This group saw an improvement in their DNA fragmentation rate from an average of 22% prior to taking the antioxidant therapy to an average of 9.1% after they received antioxidant therapy. The group that was given placebo instead of antioxidant therapy saw not improvement in their DNA fragmentation. <br /><br /> Here is another study that shows that the rate of pregnancy using ICSI was significantly increased in patients that were given 2 months treatement of Vitamin C and Vitamin E.<br /><br />http://humrep.oxfordjournals.org/cgi/content/full/20/9/2590<br /><br />In this case male patients with high DNA fragmenetation rates who had previously failed ICSI were given 2 months of Vitamin C and Vitamin E (recommend 500 mg of each twice a day). Of the patients treated 76% saw an improvement in their DNA fragementation and a second ICSI procedure was preformed. During the second ICSI procedure there was a clinical pregnancy rate of 48.2% versus 6.9% rate pre-treatment.<br /><br /><br />This information suggests that mean should try treatment with Vitamin C and Vitamin E before looking at more invasive treatments such as having sperm removed from the testes.<br /><br /><br />I just found this information and have started this treatment with my hubby, however he has been taking Coast Fertility vitamins for men and has seen his DFI go from 29% to 21% in a couple of months, so I do thing that vitamins work at least in some cases. <br /><br />I hope that this is helpful. Take Care and GoodAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-35084927190546953682010-02-10T22:27:48.363-08:002010-02-10T22:27:48.363-08:00Great Post.....
I found your site on stumbleupon ...Great Post.....<br /><br />I found your site on stumbleupon and read a few of your other posts. Keep up the good work. I just added your RSS feed to my Google News Reader. Looking forward to reading more from you down the road!<br /><br />Thanks for sharing....Egg Donorshttp://surrogacyabroad.com/egg_donor.htmlnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-63470451999666584392009-02-24T05:04:00.000-08:002009-02-24T05:04:00.000-08:00To clarify they like the fragmentation to be under...To clarify they like the fragmentation to be under 30% and anything under 15% is great and my husbands was only 6% :)Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-48853106425991477542009-02-24T05:00:00.000-08:002009-02-24T05:00:00.000-08:00My husbands SDNA test showed he's in the high fert...My husbands SDNA test showed he's in the high fertility category so he's fine. He's never done acupuncture or supplements(that was me)Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-21257231441856166662009-02-23T20:34:00.000-08:002009-02-23T20:34:00.000-08:00Amy 2... I am on my second IVF/ICSI cycle (shootin...Amy 2... I am on my second IVF/ICSI cycle (shooting for March 6th) and I also discovered after my first IVF/ICSI cycle that my husbands DFI was high. I was shocked that his sperm specialist did not think it was important to tell my doctor. It seems clear to me that this is a very important factor. It only makes sense. Anyway, you are doing the right thing with the antioxidants and acupunture. Luckily I started my husband on antioxidants and "Fertile ONE for Men" over 6 months ago and his sperm has shown signs of improvement. If your husband will stick to acupunture - great. My husband quit going after 5 months. IT could take up to 9-12 months to see improvements. Some men do not have the patience for it. And although he has not been tested in 6 months for DFI, during this IVF/ICSI cycle, he will be having his sperm removed directly from his testes. I will let you know the outcome. The first IVF/ICSI, we had 7 embryos - 4 perfect, 3 in and nothing. I am hopeful this time now that we are doing testicular sperm removal!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-74118019304543002472008-12-01T09:46:00.000-08:002008-12-01T09:46:00.000-08:00Anonymous-I had this test done recently through th...Anonymous-I had this test done recently through the Sher institute and my hubby's came back excellent at only 6% fragmentation. I highly recommend going IVF/ICSI with testicular sperm. Where did you get the test done? I'm shocked your RE didn't tell you that you need IVF/ICSI to get pregnant.Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-35440744550019806762008-12-01T08:54:00.000-08:002008-12-01T08:54:00.000-08:00My husband has a fragmentation rate of 48%. We hav...My husband has a fragmentation rate of 48%. We have been trying for 1 and 1/2 years now. Currently we are trying antioxidant and acupunture therapy to see if we can get a reduction. My fertility doctor did not recommend IVF right now. He wants us to try FSH therapy first to increases our odds. IVF is our last resort. But now I'm thinking of asking him about ICSI with testicular sperm I have red some papers that say that testicular sperm show less degree of fragmentation compared to ejaculated sperm. <BR/><BR/>I am curious to know if there are couples out there who concieved even with a high rate of fragmentation.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-71009830072587195562008-09-06T13:25:00.000-07:002008-09-06T13:25:00.000-07:00Does anyone know how the Anonymous girl's IVF/ICSI...Does anyone know how the Anonymous girl's IVF/ICSI/TESE go? I am in the middle of mine and would like to hear some good news from someone :-)Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-65520996424942501322008-07-15T06:15:00.000-07:002008-07-15T06:15:00.000-07:00Quote:"This post seems to indicate that it may be ...Quote:<BR/><BR/>"This post seems to indicate that it may be possible to lower the fragmentation level. What are some ideas for accomplishing this? I'll try anything at this point."<BR/><BR/>hmmm...good question. I'd actually have to research that one. Not all doctors even believe in this test. Actually lots of them don't do this test at all. Some thing's I've read says to take vitamins (like fertility blend for men) and that over time it may be able to improve the quality of sperm. I guess I'd have to find out what causes DFI to happen in the first place. I mean men aren't born with all their sperm like woman are eggs. Men replenish about every 3 months. So essentially you'd think this is fixable (unless it's genetic and then it may be a tad harder but I don't think it's impossible)<BR/><BR/>I'll have to do more research on the topic. if I find anything I'll make another blog entry on it.Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-83309125469877529112008-07-14T17:11:00.000-07:002008-07-14T17:11:00.000-07:00This post seems to indicate that it may be possibl...This post seems to indicate that it may be possible to lower the fragmentation level. What are some ideas for accomplishing this? I'll try anything at this point.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-89419869233900362432008-06-27T15:24:00.000-07:002008-06-27T15:24:00.000-07:00Has your Doctor recommended TESE for your DH as a ...Has your Doctor recommended TESE for your DH as a means to get at less fragmented sperm? We are doing our 2nd round of IVF/ICSI this month and DH will do TEST due to his high level of fragmentation and our low fertilization rate with our first cycle.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-51930984083981360712008-06-17T07:23:00.000-07:002008-06-17T07:23:00.000-07:00I'm brain dead today. I'm not following what you a...I'm brain dead today. I'm not following what you are saying.Amyhttps://www.blogger.com/profile/05141404945991036043noreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-22847786861200213782008-06-17T07:13:00.000-07:002008-06-17T07:13:00.000-07:00But in the instances of blood disorders and cystic...But in the instances of blood disorders and cystic fibrosis in children, the two biological parents must be on hand. I know how children can matter to some but the donated children have problems all of their own.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-232366517985764330.post-42691944447773688562008-06-16T05:34:00.000-07:002008-06-16T05:34:00.000-07:00I had a consult with Dr. Schoolcraft at CCRM at on...I had a consult with Dr. Schoolcraft at CCRM at one point to go over my case. When I mentioned that my DH had a SCSA result of 29.8% and asked if I should have the test repeated since it had been a few years, he told me it was not an issue; that they have seen successful pregnancies with results as high as 60 something percent. He really did not seem to put much value on this test. Maybe there is another Dr. there that does though?<BR/><BR/>Regarding this article from Resolve, I would check to make sure it wasn't actually written by the man who designed the test. I noticed that the majority of articles I found like this were, in fact, written by him.<BR/><BR/>Don't get me wrong. I honestly am just as confused as you about this whole issue and do feel that it's asking a lot to have someone believe that sperm quality plays no role at all in things.Stacihttps://www.blogger.com/profile/06147967839861326283noreply@blogger.com