Sunday, April 27, 2008

multinucleated embryo cells

Here is a study I found. I don't know why I sit here and do this to myself. I guess it's because I'm obsessed with having to know everything. I can't wait to talk to my embryologist on Monday. I'm going to pick her brain. They have done lots of their own studies over the years so she can tell me what my odds of pregnancy are. Thank goodness we finally got at least 1 perfect embryo. I've been doing IVF for 1 year and that has never happened. Boston IVF did say that I had a perfect 8 cell (day 3) embryo with my first IVF but their criteria is not nearly as strict as my current Re's office so I don't have much faith in them.

I guess judging by the research I've done that my embryo's are considered chromosomally abnormal. There are tests we can do to check if that is the case however in order to do those tests my embryo's have got to make it to day 3 (which they normally do) on day 3 they take some cells and do a biopsy on them to see if they are abnormal or not. However it takes a few weeks for the results to come back so they would grow the embryo's to day 5 and freeze them. My embryo's never make it to day 5. So essentially I could get the test done but odds are I'd have no embryo's to freeze. I suppose then at least we'd have an answer.

I believe this study was done back in 1996 so I'm sure there have been new developments. Which is one reason I want to talk to my embryologist. She said she could email me some of her studies so I might take her up on that offer.

Titre du document / Document title

The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities

Auteur(s) / Author(s)

KLIGMAN I. (1) ; BENADIVA C. (1) ; ALIKANI M. (1) ; MUNNE S. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) The Center for Reproductive Medicine and Infertility, The New York Hospital-Cornell Medical Center, New York, NY, ETATS-UNIS

Résumé / Abstract

The purpose of the present study was to determine whether the presence of one or more multinucleated blastomeres during early embryonic development is associated with chromosomal abnormalities in sibling blastomeres of that embryo. Embryos with multinucleated cells (n = 47) detected on day 2 or 3 of development were compared to dividing embryos without multinucleation. Arrested embryos were excluded from this study. Chromosome abnormalities were detected using fluorescent in-situ hybridization (FISH) with X, Y, 18 and 13/21 chromosome-specific probes. Of 47 embryos included in this study, 76.6% were chromosomally abnormal, compared to 50.9% in the control group (P <>


Bee Cee said...

All this inof is really useful. I think I have a problem with egg quality so its useful to learn more about it.

Hope the chat with the doc has gone well.

M said...

Oh, I am so glad you had a good transfer and have such a good-looking embie!! Great, great news!

Heidi said...

Hi Amy, just found your blog. I'm doing my IVF #3 at CCRM this month. I decided against PGD for the same reason - our embryos probably won't make it. I'll add you to my blog reader and read more about your story, but just wanted to say hi for now.

Amy said...

Heidi I can't view your profile to see your home page. I have actually been re thinking doing some genetic testing. probably not PGD though. Someone told me about polar body testing since we are pretty sure the problem is with me. I'll either try that or CGH. I mean if my embryo's are going to die anyway might as well make them useful for something right?

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